It seemed to grow over 2 years, when a magnetic resonance imaging investigation measured it at 6 cm in diameter. A 35-year-old man noticed a tumor of his left elbow after a trauma. All patient information has been de-identified. The study was approved by the Regional Committee for Medical and Health Research Ethics, South-East Norway (Regional komité for medisinsk forskningsetikk Sor-Ost, Norge,, REC no S-07474a). We present here cytogenetic data on another case of pseudoangiomatous pleomorphic/spindle cell lipoma which showed loss of 13q material.Įthics statement.

Genetic information on pseudoangiomatous pleomorphic/spindle cell lipoma is restricted to one case only ( 8) in which fluorescence in situ hybridization (FISH) with a probe for the forkhead box O1 ( FOXO1) gene, which maps to chromosome sub-band 13q14.11, showed a signal pattern indicating monoallelic loss of the gene in 57% of the examined cells. The pseudoangiomatous pleomorphic/spindle cell lipomas were mostly found in the neck (seven patients) and shoulders (four patients), but have also been seen in the cheek, chest, chin, elbow, finger, subscapular region, and thumb. To date, only 20 patients have been described in the literature with this diagnosis, 15 of whom were males ( 1- 10). The tumors had ‘the features of typical spindle cell lipoma but, in addition, exhibited irregular and branching spaces with villiform connective tissue projections, giving a striking angiomatoid appearance’ ( 1). Pseudoangiomatous pleomorphic/spindle cell lipoma is a rare subtype of pleomorphic/spindle cell lipoma first described by Hawley et al. Pseudoangiomatous pleomorphic/spindle cell lipoma.Results confirm the (cyto)genetic similarity between pseudoangiomatous pleomorphic/spindle cell lipoma and spindle cell lipomas. Among them was loss of chromosome 13 material. Conclusion: Several acquired genomic aberrations were found in the tumor. FISH analysis revealed that the deleted region contained the RB1 gene (13q14.2) and the part of chromosome arm 13q (q14.2-q14.3) in which spans the TRIM13 gene, the two non-coding RNA genes, DLEU1 and DLEU2, and the genetic markers RH44686 and D13S25. Results: G-banding of tumor cells showed complex karyotypic changes including loss of chromosome 13. Materials and Methods: G-banding and FISH analyses were performed on a pseudoangiomatous pleomorphic/spindle cell lipoma. Genetic information on pseudoangiomatous pleomorphic/spindle cell lipoma is restricted to a single case in which deletion of the forkhead box O1 (FOXO1) gene was found, using fluorescence in situ hybridization (FISH). Only approximately 20 such tumors have been described. Background: Pseudoangiomatous pleomorphic/spindle cell lipoma is a rare subtype of pleomorphic/spindle cell lipoma.

Spindle cell lipoma